Endocrine Abstracts

Background and Aims: to study the clinical significance of the s E- selectin (CD 62) in the serum of patients with Type 1 Diabetes and Microangiopathy (diabetic nephropathy (DN) and retinopathy (DR).Materials and Methods: 32 patients (14 men & 18 women, age mediana 26,4 years) were under supervision in the period from 1999 to 2001 years. The cohort examined was subdivided into 3 groups:1. with newly diagnosed diabetes (n = 11) ...

Background: Sodium glucose co-transporter 2 inhibitors reduce the incidence of cardiovascular events in patients with type 2 diabetes mellitus based on the results of recent cardiovascular outcome studies. Herein, we investigated the effects of long-term treatment with empagliflozin on biochemical and immunohistochemical markers related to atherosclerosis development in apolipoprotein E knockout [Apo-E(−/−)] mice.Methods: At the ag...

Introduction: Obesity is a global public health problem and is associated with metabolic syndrome and dyslipidemia as well as very often with non-alcoholic steatohepatitis (NASH).Aim & methods: The aim of the present study was to evaluate the preventive and curable role of vitamin E and pioglitazone (thiazolidinedione-type) in NASH patients with or without metabolic syndrome. 51 patients with NASH were divided into two groups: 26 patients with insuli...

Since July 2005 our centre has offered an e-mail enquiry service to General Practitioners. This service was established for two reasons, firstly to create a more efficient way of dealing with clinical enquiries from primary care and secondly with a long term objective to reduce GP referral rates. The service is manned by Endocrine/Diabetes Specialist Registrars and is part of their training commitment. Compared to telephone calls it gives the registrar more chance to think thr...

Objective: higher aldosterone (aldo) levels are associated with increased risk of cardiovascular ischemic events and mortality. It has been demonstrated that aldo accelerates the development of aterosclerosis in apolipoprotein E knockout mice (ApoE KO). Ketogenic diet (KD) positively impacts several cardiovascular risk factors, yet its effect on atherosclerosis, is elusive. We hypothesize that, KD protects from development of atherosclerotic plaques in ApeE KO mice, a murine m...

Objectives: To study the effect of epithelial-to-mesenchymal transition (EMT) on hormone expression in gonadotroph non-functioning pituitary neuroendocrine tumours (NF-PitNET).Background: Gonadotroph PitNETs can express FSH and LH or be hormone negative, however they rarely secrete hormones. During tumour development, epithelial cells develop a mesenchymal phenotype. This process is characterised by decreased membranous E-cadherin and translocation of E-...

Purpose: The aim of this study was to evaluate the effects of methomyl 25%WP (Lannate, carbamate broad spectrum insecticide) on the reproductive parameters in female Wistar rats during pregnancy and the possible protective role of vitamin E against methomyl-induced toxicity.Methods: The animals were randomly divided into four groups, eight of each. Group I served as control; Group II received orally a dose of methomyl (Met, 10 mg/kg per day), Group III w...

Archipelago/hCdc4/Fbw7 is the F-box protein specific for recognising and binding phosphorylated cyclin E and targeting it for ubiquitination. Mutations in Archipelago that prevent it from binding to phoshorylated cyclin E have been described in various human cancers including breast, ovarian and endometrial tumours. Previous studies have suggested that cyclin E is over-expressed in corticotroph tumours and other pituitary adenoma subtypes, and we postulated that this may be se...

IntroductionThe European Registries for Rare Endocrine Conditions (EuRRECa) project was launched in February 2018 and aims to support the needs of the endocrine and bone community by facilitating the collaboration between patients, health care professionals and researchers across Europe and beyond. It is closely linked to the European Reference Networks on Rare Endocrine Conditions (Endo-ERN) and Rare Bone Diseases (ERN BOND) with its registry EuRR-Bone....

IntroductionFollowing the onset of the COVID-19 pandemic in early spring 2020, there was a need to identify the burden of this infection on people with rare endocrine conditions. The European Registries For Rare Endocrine Conditions (EuRRECa) was launched in 2018 in collaboration with Endo-ERN, ESPE and ESE to support the needs of the wider endocrine community. The project consists of an e-reporting (e-REC) platform that allows monthly reporting of new c...